not generalizable to other RCTs. Goal Attainment Scaling (GAS); Global Measures. Clinician Interview-Based Impression of Change plus caregiver input ( CIBIC. interview [CIBIC-plus]). The ADAS- cog, disease assessment in dementia scale, and neuropsychiatric inventory are recorded by supervising site investigator, but . The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC -Plus), is widely used in antidementia drug trials. It comprises Likert scales for.

Author: Dar Akiramar
Country: Monaco
Language: English (Spanish)
Genre: Business
Published (Last): 10 December 2004
Pages: 380
PDF File Size: 9.83 Mb
ePub File Size: 17.68 Mb
ISBN: 421-9-44408-939-4
Downloads: 94197
Price: Free* [*Free Regsitration Required]
Uploader: Nikolkis

Search Our Scientific Publications & Authors

Sign In Join Now. Patients were randomized to donepezil 10 mg daily or placebo for 24 weeks. Dement Geriatr Scle Disord 4;24 2: Measurement of observer agreement. We examined how this change compared with measures of clinical meaningfulness.

The interviewers interviewed patients and caregivers twice, once at baseline and once cibid a follow-up period of 1—24 weeks. Galantamine treatment in Alzheimer’s disease with cerebrovascular disease: A new rating cibi for Alzheimer’s disease.

A week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease. Dement Geriatr Cogn Disord 3;25 5: However, the effect of memantine on patients with mild-to-moderate AD is unclear. Global measures used in treatment trials in dementia encompass two distinct categories: Assessment Procedure First, the central raters watched the videotaped CIBIC interviews of patients and caregivers to assess the patients by subscales at baseline and after the follow-up period.

The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: To evaluate efficacy and safety of galantamine for patients with vascular dementia VaD.


This report is based on the data of a clinical trial that was sponsored by Dainippon Sumitomo Pharma Co. Open in a separate window. However, none of medical treatment can stop or reverse the underlying neurodegenerative of AD at present.

CIBIC Plus-J Assessment Using a Videotaped Method in Alzheimer’s Disease Patients

The aim of the present report was to examine the reliabilities of the subscale items and investigate their relationships with CGIC. Acupuncture for zcale with mild to moderate Alzheimer’s disease: Int Psychogeriatr Jun;19 3: To evaluate the effects of galantamine withdrawal, and compare this with uninterrupted therapy, two 6-week double-blind withdrawal studies Studies 1 and 2 were performed.

Currently, there are no medications approved for treating patients with VaD.

Whether it is also appropriate for severe AD in Chinese patients remains unknown. Prog Lipid Res Jan 24; Interviewers agreed to their voice being recorded before each interview. Curr Alzheimer Res Feb;5 1: The role of memantine as a treatment for Alzheimer’s disease AD has been controversial.

Please review our privacy policy. The effects scxle DLn-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: As a result, the kappa coefficient showed a moderate agreement of 0.

We also wish to thank the following clinical research associates who were involved in collecting data for the study: ICC determined by the two-way layout model was 0. Cognitive impairment and dementia are common features of Parkinson’s disease PD.

CIBIC Plus-J Assessment Using a Videotaped Method in Alzheimer’s Disease Patients

Since the public nursing-care insurance system started in in Japan, there has been an increasing tendency for caregivers such as family members to spend less time with their patients. The measurement of observer agreement for categorical data. Acta Neurol Scand Feb 29; 2: Epub Feb Combination therapy for patients with Alzheimer disease AD was suggested, but the additional benefit of combination therapy is still controversial.


In this retrospective, hypothesis-generating analysis, we investigated whether cibiv in AD were associated with greater treatment benefits with rivastigmine. To evaluate the efficacy and safety of donepezil for severe Alzheimer disease AD. Preclinical trials showed that dln-butylphthalide NBP is effective for cognitive impairment of vascular origin.

The central raters consisted of eight AD experts. Table 1 Summary scal baseline demographic characteristics of patients. No secular trend and high variability for ADAS-cog change among placebo groups from clinical trials: Scae kappa was 0. Materials and Methods Informed Consent Informed written consent was obtained from patients and caregivers before their enrollment into this clinical trial.

CIBIC-plus Publications | PubFacts

Latrepirdine for Alzheimer’s disease. Neurology Jul;69 5: Effects of cholinesterase inhibitors in Parkinson’s disease dementia: Guideline on medicinal products for the treatment of Alzheimer’s disease and other dementia.

Fufangdanshen FFDS tablets Radix Salviae miltiorrhizae formula tablets are a traditional Chinese medicine that has been reported to improve memory.