CPSP, previously known as Dejerine-Roussy syndrome and thalamic pain syndrome, is a feared complication of cerebrovascular accidents and has been. Stroke and pain can sometimes result in Dejerine-Roussy syndrome. Available treatments include antidepressants, anticonvulsants, and. Due to the high clinical variability in presentation of Déjerine-Roussy syndrome, it is impossible to predict which patients with a thalamic stroke will develop pain.

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Dejerine–Roussy syndrome

Support Center Support Center. The paddle is inserted through two burr holes or via the temporary removal of a small piece of the skull craniotomy. The thalamus is a structure deep in the brain that acts as the key hub in sensory processing, in synchrony with the cortex. Furthermore, tumours including metastasesdemyelinationand abscesses involving the thalamus can also cause an identical syndrome 5,6. Symptoms dejdrine generally not treatable with ordinary ruossy.

Although an ischemic event precedes most central post-stroke pain, the pain can also happen after hemorrhagic stroke which can be either intracerebral or subarachnoid hemorrhage. In contrast, the right hemisphere does the opposite, and will focus on the discrepancy, and motivate action to be taken to restore equilibrium. First can be a spontaneous, constant pain described as burning, aching, pricking, freezing, and squeezing.

Central pain syndrome can be limited to a specific area of the body such as the hands or feet or may be widespread over a large portion of the body. Complications Reduces the quality of life. Related Disorders Symptoms of peripheral neuropathic pain e. Author Information Authors Muhammad U.

Dejerine–Roussy syndrome – Wikipedia

However, researchers now know that damage to the pain-conducting pathways anywhere along the neural axis, from the spinal cord to the sensory cortex, can cause central pain syndrome, including cases following injury or a stroke. Allodynia and dysaesthesia replace numbness between one week and a few months after a thalamic stroke. You can also scroll through stacks with your mouse wheel or the keyboard arrow keys.


Although the thalamus is the location of the lesion implicated in this syndrome, central post-stroke pain can also occur due to lesions at any level of the spinothalamic pathwaysuch as in patients with the lateral medullary syndrome or with cortical lesions 2,7.

Studies have shown that amitryptiline 75 mg is superior to carbamazepine, according to a three-phase crossover randomized clinical trial. NSAIDs generally provide little to no relief for individuals with central pain syndrome. Such invasive surgeries are rarely used for individuals with central pain syndrome anymore.

Affilations 1 University of Missouri, Columbia. There are several etiologic theories proposed which include central imbalance, central disinhibition, central sensitization, the Grill illusion theory or thalamic changes, and the inflammatory response of the neural pathway involved. In one case reported in the medical literature, this procedure immediately and completely relieved pain in the affected individual.

Henriette Klit and his co-workers propose a stepwise approach.

Dejerine-Roussy Syndrome

And thus it was thought that the syndrrome associated after stroke was part of the stroke and lesion repair process occurring in the brain. However, much more research is necessary in this area. Retrieved from ” https: The risk of lethal brain hemorrhage is small, but real. However, the disorder can also appear immediately after an injury or within a day.

Synonyms or Alternate Spellings: The central post-stroke pain occurs more frequently in those with acute stroke and larger lesions, but no characteristic finding on computed tomography CT brain scan of the patients with central post-stroke pain is identified. Its genesis is highly controversial, and several researchers deny its existence as a stand-alone syndrome; the American Medical Association —for one- believes that the sympathetic nervous system plays no direct role.


Canavero S, Bonicalzi V. The nature of the pain varies considerably between patients, but is often moderate to severe in intensity, can be either persistent or episodic, can be either spontaneous or evoked e. In addition, it has been proven that the posterior insula receives a substantial amount of the inputs of the brain, and can be treated with visual, kinestheticand auditory inputs.

For information about clinical trials conducted in Europe, contact: Expert Review of Neurotherapeutics. Dejerine-Roussy’s syndrome expresses the semiology of the relay nuclei. In these cases, numbness is replaced by burning and tingling sensations, widely varying in degree of severity across all cases. Most patients experiencing allodynia, syndromf pain with touch and pressure, however some can be hypersensitive to temperature.

Any lesion on the spinothalamic rpussy, anywhere throughout its course in the central nervous system CNScan cause central post-stroke pain. November Learn how and when to remove this template message.

This component may be the predominant complaint as it happens daily with pain-free intervals of a few hours. Parietal Pseudothalamic Pain Syndrome: Those project from thalamus to the insular cortex or anterior cingulate region, ayndrome the mechanism is undefined. Neuropsychology of thalamic lesions has demonstrated the regulatory role performed by the thalamus within each hemisphere and in the relative activation of each hemisphere.

Treatment Treatment for central pain syndrome remains unsatisfactory in that, although most patients find synfrome relief, complete control remains infrequent. The syndrome was named after them after their deaths. Epub Jul 3.

Repetitive transcranial rpussy stimulation r TMS: History and Physical Central post-stroke pain is a kind of hemidystonia that typically involves the areas of the body affected by stroke.

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